Wednesday, July 11, 2012

Is there a preventative therapy for aggressive behavior?

Mental health issues are posing many problems in the lives of many people all over the world. Aggressive or angry behavior is one of the mentalhealth issues that troubles a number of people and it would certainly help to know more about its preventative measures.
A new research has found something within angry mice that is also found in humans and the means to shut it off. When a mouse acts hostile, it has been found that this happens because a receptor within its body has malfunctioned. This discovery is very important from the point of view of treatment of extremely antagonistic behavior even if there might be no possible cure for the same. A specific gene disposition meant for low levels of an enzyme (monoamine oxidase A, or MAO A) was identified in these violent mice by Marco Bortolato of University of Southern California and Jean Shih from the School of Pharmacy. The lower the levels of MAO A, the more are the chances that these mice will exhibit violent behavior. To continue with their studies, they found that the mice that were deficient of this enzyme reacted with aggression whenever they were stressed. Bortolato found that though the same type of mutation that is studied in mice is associated with criminal and extremely vicious behavior in humans, the reason for this type of conduct has not yet been comprehended.
It was observed that extremely high levels of electric shocks were necessary to activate a particular brain receptor in the pre-frontal cortex known as NMDA in both types of mice: those mice that were exceedingly vicious and hot-tempered and even those that lacked in the enzyme MAO A. Once activated, the NMDA, though it managed to work, remained active for only a brief period of time.
Based on the above examination, researchers have come to the conclusion that aggression in mice is moderated after blocking the above-mentioned receptor. Hence this discovery is very useful for applying the same type of remedy in the form of treatment to human beings too. Thus this detection holds a lot of promise in the field of preventative therapy.
Such type of extremely aggressive behavior is also exhibited by people suffering from common physiological disorders like Alzheimer’s disease and autism. Such observations are tremendously significant from the point of view of using certain preventative measures in place of aggression. This has paved way for the anticipation that aggression or angry behavior can be hopefully kept in check. For this, the potential side effects of drugs that lessen the action of the aggression receptor under consideration have to be carefully studied.
Thus a breakthrough in this field in the form of preventative therapy for the treatment of mental health in the future will bring a welcome relief for everyone.

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